Treatment of systemic sclerosis with antithymocyte globulin

Systemic lupus erythematosis with severe aplastic anemia successfully treated with rituximab and antithymocyte globulin

Hematologic disorders are very common in Systmic lupus erythematosus (SLE).First presentation of SLE with severe aplastic anemia (SAA) is extremely rare. We report a patient with the diagnosis of secondary SAA associated with SLE. Conventional therapy was not effective. She received Rituximab (RTX) and Antithymocyte globulin (ATG) therapy, her response was satisfactory finally. Her hematologic ...

Repeat course of rabbit antithymocyte globulin as salvage following initial therapy with rabbit antithymocyte globulin in acquired aplastic anemia.

Facilitation of metastasis by antithymocyte globulin.

Antithymocyte globulin (ATG) increases the number, size, and rate of appearance of pulmonary métastasesin mice from implants of the syngeneic Lewis lung carcinoma (3LL) without significantly increasing the weight of the primary tumor. An attempt was therefore made to deter mine whether this effect was due to an earlier release of malignant cells from the primary tumor or to facilitation of the...

A Multicenter Trial of Antithymocyte Globulin in

One hundred fifty patients with bone marrow failure were treated in three groups with antithymocyte globulin (ATG; Upjohn. Kalamazoo, Ml) in a multicenter trial. Patients were assessed at 3, 6, and 1 2 months after initiation of treatment by three criteria: transfusion independence. clinical improvement, and blood counts. Group I consisted of 77 patients with acute severe aplastic anemia. rando...

Antithymocyte globulin and transplants for aplastic anemia.

have completed a study on the use of antithymocyte globulin (ATG) as part of the conditioning regimen for severe aplastic anemia (SAA) patients, undergoing an allogeneic stem cell transplant (HSCT) from matched sibling (MSD) or unrelated (UD) donors. The Authors have found that rabbit ATG (thymoglobulin, Sanofi, France), as compared to horse ATG (ATGAM, Pfizer, USA) is associated with less acut...